008. ANCA BEYOND MPO & PR-3: THE CLINICAL UTILITY OF AN EXPANDED ANCA PROFILE
نویسندگان
چکیده
منابع مشابه
Myeloperoxidase-antineutrophil Cytoplasmic Antibodies (MPO-ANCA) and Proteinase 3-ANCA without Immunofluorescent ANCA Found by Routine Clinical Testing.
OBJECTIVE Concurrent testing for serum antineutrophil cytoplasmic antibodies (ANCA) by indirect immunofluorescence (IF) and by antiproteinase 3 (PR3)/antimyeloperoxidase (MPO) antibody assays may identify patients with PR3-ANCA or MPO-ANCA despite a negative IF (IF-negative MPO/PR3-positive); however, the significance of this result is not clear. We sought to determine whether IF-negative, MPO/...
متن کاملThe clinical utility of ANCA positivity.
It is six years since a leader in the Annals reviewed the performance of antineutrophil cytoplasmic antibodies (ANCA) in clinical practice.' At that time there was increasing confidence in the value of ANCA testing in the diagnosis ofWegener's granulomatosis and related primary vasculitides. Sensitivity of cANCA for Wegener's granulo-matosis was reported as 500/o-96% and specificity was 900/o-1...
متن کاملMPO-ANCA associated vasculitis with mononeuritis multiplex following influenza vaccination
Background Although influenza vaccines are generally safe and effective, a variety of autoimmune phenomena have been reported after vaccination over the past years, such as Guillain-Barre syndrome, rheumatoid arthritis, pemphigus vulgaris, psoriasis, giant cell arteritis and anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). Case report We describe the case of a 67-year ...
متن کاملMembranous Nephropathy With MPO-ANCA-Associated Crescentic GN
INTRODUCTION Antineutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (GN) is characterized by necrotizing and crescentic GN with paucity of immunoglobulin (Ig) and complement deposition, which is also known as pauci-immune crescentic GN. Membranous nephropathy (MN) is characterized by the formation of subepithelial immune deposit with resultant changes in glomerular basement ...
متن کاملANCA-positive vasculitis: Clinical implications of ANCA types and titers.
INTRODUCTION Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune disease that can affect multiple organs, the kidney being one of the most affected. Apart from the diagnostics value of ANCA, they have also been advocated as biomarkers of the disease activity. Recently, the genetic changes found in polyangiitis associated with serine-protease proteinase 3 (PR3)-ANC...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2019
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/kez057.007